SCPA233 Lung- Aspergillosis

คำอธิบายชิ้นเนื้อ

Pulmonary aspergillosis is a fungal infection in the lung caused by inhalation of airborne conidia of Aspergillus species. Aspergillus can be found in the environment and usually cause limited infection such as within the nasal cavity. In immunocompromised host, however, Aspergillus infection can spread to the lung and can be found concomitantly with tuberculosis or other chronic obstructive pulmonary disorders. Gross morphologically, the outer surface of the lung may appear normal. X-ray may show intracavitary mass (fungal ball) surrounded by crescent of air (Monad sign) that may rotate in response to gravitational or positional change. Histopathology shows fungal ball (A) embedded within the lung parenchyma (B) and invasion into the mucosal membrane of the lung (C). H&E staining of Aspergillus species show uniform thickness 2.5-4.5 um in diameter septate hyphae with acute angle (45 degrees) dichotomous branching (D).